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![China Manufacturer Supply High Quality 3-Amino-3-azabicyclo[3.3.0]octane hydrochloride CAS 58108-05-7 for sale](/uploads/image/20251222/3-Amino-3-azabicyclo[3.3.jpg "China Manufacturer Supply High Quality 3-Amino-3-azabicyclo[3.3.0]octane hydrochloride CAS 58108-05-7 wholesale")
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3-Amino-3-azabicyclo[3.3.0]octane hydrochloride is a nitrogen-containing bridged bicyclic organic compound sold as a hydrochloride salt for stability. It is a valuable synthetic intermediate in medicinal chemistry.
Key Features & Uses:
Rigid Scaffold: Its fused, three-dimensional azabicyclo[3.3.0]octane structure provides rigidity and a specific spatial orientation for attaching other molecular fragments. This is crucial for designing drugs that selectively bind to biological targets.
Versatile Building Block: The primary amine group (-NH₂) allows it to be easily incorporated into larger, more complex molecules.
Primary Application: It is used in pharmaceutical R&D to create potential drug candidates, especially for central nervous system (CNS) targets and enzyme inhibitors. The structure is found in research compounds targeting:
Neurological disorders (e.g., as a fragment for nicotinic acetylcholine receptor ligands).
Antiviral agents.
Pain management (e.g., in analogues of potent analgesics).
In short, it is a specialized chemical "Lego brick" used by researchers to build novel, rigid molecules with potential therapeutic effects, primarily for neurological and psychiatric conditions.
Items | Specifications | Results |
Appearance | Off-white or pale yellow crystal or crystalline powder | Pale yellow crystalline powder |
Melting point | 165-172℃ | 167-169℃ |
Loss on drying | ≤0.50% | 0.30% |
residue on ignition | ≤0.20% | 0.10% |
2-nitroso-octahydrocycl openta[c]pyrrole | ≤20ppm | 0.4ppm |
Assay | ≥98.50% | 99.60% |
Conclusion | The product conforms to the above specifications. | |
3-Amino-3-azabicyclo[3.3.0]octane hydrochloride is a chemically synthesized, nitrogen-rich organic compound primarily used as a specialized building block in pharmaceutical research and drug discovery.
Bicyclic Core: Its core is a rigid, fused azabicyclo[3.3.0]octane scaffold—two five-membered rings sharing atoms, with a nitrogen ("aza") at a bridgehead position. This creates a defined three-dimensional shape.
Functional Handle: It has a primary amine group (-NH₂) attached to that bridgehead nitrogen, providing a key site for chemical reactions.
Salt Form: It is stabilized as a hydrochloride salt, making it a stable, solid, and water-soluble material for laboratory use.
This compound is not a drug itself but a high-value intermediate. Its main application is in medicinal chemistry to construct more complex molecules. Its rigid, 3D structure is particularly valuable for:
Central Nervous System (CNS) Drug Discovery: The scaffold is used to create potential treatments for neurological and psychiatric disorders. It serves as a core structure in research ligands for nicotinic acetylcholine receptors (nAChRs), targeting conditions like cognitive decline, depression, and pain.
Enzyme Inhibition: The structure can be incorporated into molecules designed to selectively inhibit specific disease-relevant enzymes.
Creating Molecular Complexity: Chemists use it as a sophisticated "Lego brick" to introduce conformational restraint into a drug candidate, which can improve its potency, selectivity, and metabolic stability.
In summary: It is a rigid, bicyclic amine used by researchers as a key intermediate to synthesize novel compounds, especially for potential neurological/psychiatric therapeutics.
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